Ethylene Oxideによる気管狭窄の実験的研究 (予報)

主として病理組織学的観察から

抄録

The authors previously reported two clinical cases of tracheal stenosis in children following intratracheal intubation and suggested a possibility of chemical effect of residual ethylene oxideused for sterilization of the tube on the tracheal mucosa.
In the present study, animal experiments were performed on 7 dogs in order to investigate the effect of residual ethylene oxide on the laryngotracheal mucosa. The result suggested that there was a positive relationship between the aeration time after sterilization and the degree of histological changes in the mucosa.
Based on the result of the present study, it was suggested that aeration time should be longer in order to avoid possible damage to the airway mucosa.