気管気管支分泌液の蛋白分解酵素に関する研究

第2報 血管作動薬によるラット分泌液中 Plasminogen Activator の変動

抄録

In order to clarify the release mechanism of the plasminogen activator in the tracheobronchial secretion of rats, the effect of some vasoactive drugs on its activity in the secretion was studied in this experiment The results obtained from this experiment were as follows After the injection of noradrenalin, the blood pressure was temporarily elevated and the fibrinolytic activity in the circulatory blood was also elevated, and then the activity of plasminogen activator in the secretion increased On the other hand, after the injection of atropine sulfate, the blood pressure and fibrinolytic activity were not changed and then the activity of plasminogen activator in secre tion decreased in comparison with the activity after the injection of noradrenalin
From these results it was suggested that the release of plasminogen activator into the lumen of the respiratory tract might be partly regulated by neurogenic system