気管支喘息における室内塵抗原による試験管内ヒスタミン遊離試験に関する臨床的研究

抄録

An in vitro histamine release test in the whole blood with house dust antigen was performed in 102 asthmatics. The following results were obtained.
1) The percentage of histamine release was significantly higher in asthmatics than in healthy persons. It was also higher in the group with a positive skin test than in the group with a negative skin test (p<0.001).
2) The percentage of histamine release correlated well with the results of the skin test, the end points of the skin test and RAST scores (r=0.47, p<0.001; r=0.56, p<0.001; r=0.60, p<0.001).
3) The rate of histamine release was 72.6±19.3 percent in the group with a positive provocation test.
4) In a negative skin test, the histamine releasing rate was 3.2±3.0 percent. This result suggested that house dust antigen was estimated as a causative antigen in asthmatics when the histamine releasing rate was more than 9.2 percent.