抄録
Chronic sinusitis is one of the representative chronic respiratory inflammatory disease and is similar in some respects to chronic bronchitis. Nasal secretion from chronic sinusitics is an ideal material to study the rheological properties of respiratory fluid because it is readily obtained in large amount without contamination.
Storage modulus (G′) and loss modulus (G″) of nasal secretion from chronic sinusitics were measured using an oscillating sphere magnetic rheometer. Results of the analysis with multiple regression indicate that G′ is closely related to dry weight, sIgA and Ca iron, while G″ is closely related to dry weight, sialomucin and sIgA. Deceleration of nasal mucociliary transport observed in chronic sinusitics could be due to the rheological properties of nasal secretion and in vivo factors, such as decreased periciliary fluid and tethering phenomenon of mucus. Deceleration of nasal mucociliary transport in chronic sinusitics was improved by the treatment such as antral lavage and S-carboxymethylcysteine. This fact indicates that deceleration of nasal mucociliary transport in chronic sinusitics is not a cause of this disease but an effect of chronic sinusitis.
