The combined therapy of local intraarterial infusion (mainly the intraarterial injection) of 5-FU with simultaneously performed radiotherapy was tried on the patients with carcinoma of the larynx, the patients with hypopharyngoesophageal carcinoma and the patients with metastatic carcinoma of the cervical lymph node. All of 6 patients with carcinoma of the larynx, who had relapsed after the radiotherapy, were healed without relapse, and, in addition, the phonetic disorder did not persist. This therapeutic method is considered to be very promising not only for the therapy of the patients with hypopharyngeal carcinoma but also for the patients with metastatic carcinoma of cervical lymph node. The carcinoma in the area of intraarterial injection was healed very well in any of the patients. In general, the intraarterial injection has such various advantages as follows: (1) it is efficient and is capable of being performed as a reliable intraarterial infusion; (2) it is easy to perform; and (3) the sufficient objective of the therapy may be attained after three trials of the injection. But the drug is limited to 5-FU, and the simultaneous radiotherapy is indispensable. The result of this therapy is expected to be much better if the intraarterial injection could be performed at the sites closer to the heart.
