抄録
Drug metabolizing enzymes (DMEs) play a role in modifying drug activity and in modulating
the clearance of target compounds such as endo- and xenobiotics, small molecule drugs, steroid
hormones and dietary flavonoids. Thus, the evaluation of metabolites generated by DMEs is
required for drug development, food science and environmental assessment. Here, we generated a
library of DMEs expressed in yeast cells as a means of studying xenobiotic metabolism from early
phase metabolic screening to structural determination and evaluation. In this review, advantages of
the DME expression system are introduced as well as applications of the DME platform for
studying drug metabolism.
