抄録
The normal variation and bilateral symmetry of bone remodeling at different sites in iliac trabecular bone were studied in 2 male and 2 female adult beagle dogs to determine a suitable site for biopsy. Bone remodeling parameters were measured in transverse sections at 5mm intervals using an image analyzer. Significant differences were found in sections at different sites in the same animal in the values for the trabecular bone specific volume, mean trabecular or seam thickness, fractional formation surface, mineral apposition rate, tetracycline labelling rate, corrected mineral appositional rate, bone formation rate and period and/or trabecular bone specific surface, but these differences were not significant in adjacent sites between 10mm and 15mm from the crest. The state of bone remodeling at a site 15mm from the crest was found to be representative of that of all sections of the ilium. Less than about 10% mean variation was observed in almost all parameters of bone remodeling in symmetrical sections, but no significant differences were found in bone remodeling in sections from different sites of the left and right side except in the mean seam thickness. Symmetrical variation in the mean seam thickness of a site 10mm from the crest seemed to be different from those of three other sites. It is concluded, therefore, that symmetrical transverse sections should be taken sequentially at sites of both ilia of beagle dogs about 15mm from the crest to evaluate alteration(s) in trabecular bone remodeling associated with metabolic bone diseases or with therapeutic treatments.
