Stimulatory effects of collagen production induced by coenzyme Q₁₀ in cultured skin fibroblasts

Abstract

Coenzyme Q₁₀ (CoQ₁₀) is a well-known antioxidant and serves as an essential carrier for electron transport and proton translocation in the mitochondrial respiratory chain. CoQ₁₀ has been widely commercially available in Japan as a dietary and health supple­ment since 2001 and it is used for the prevention of lifestyle-related diseases induced by aging. Recently, it was stated that for Japan, which is facing an aging society, CoQ₁₀ has been used in many skincare products. However, the physiological actions of CoQ₁₀ in skin fibroblasts are not fully understood. In this study, we examined the effect of CoQ₁₀ on cultured human skin fibroblast. In this study, CoQ₁₀ treatment increased intracellular CoQ₁₀ level and promoted proliferation of fibroblasts. In addition, CoQ₁₀ increased mRNA expression of type I, IV, VII collagen, elastin, and HSP47, whereas CoQ₁₀ has little effect on mRNA of type II and VIII MMP. These results suggested that CoQ₁₀ has the efficacy that it increases collagen production in skin, thereby there is possible of the anti-aging by CoQ₁₀ in Japan which reached an aging society, so that it might be based on new physiological function by CoQ₁₀.