1986 年 1 巻 2 号 p. 181-188
Administration of carbon tetrachloride to rats by intraperitoneal injection caused significant increases in serum aromatic L-amino acid decarboxylase activity and serum glutamate oxaloacetate and glutamate pyruvate transaminase levels. Moreover, a significant positive correlation coefficient was obtained between the decarboxylase activity and glutamate oxaloacetate transaminase activity.
The increment of the decarboxylase activity in the serum caused by carbon tetrachloride was found to be accompanied by a decrease in the decarboxylase activity of the liver, and a significant negative correlation was found between the two enzyme activities. In contrast, no change was found in the decarboxylase activity of the kidney.
These observations suggest that aromatic L-amino acid decarboxylase occurs in the serum at least in part as a result of the leakage of the enzyme from the liver into the blood.
