Abstract
When 25 cosmetic products on the market (8 lotions, 9 foundations, and 8 creams) were set near a window and exposed to the sun for one year, the lipid peroxide levels in some creams and foundations were markedly increased, and some cosmetic products changed color and gave off a bad odor with time.
UV-irradiated creams containing lipid peroxides were separately applied at 24h intervals for 8 days in a closed patch test on the back skin of guinea pigs. Histological examination was performed on the 9th day, and hyperkeratosis, dyskeratosis, intraepidermal edema, and marked spongiosis in the epidermis and small cell infiltration in the dermis were observed.
Effect of UV-irradiated creams containing lipid peroxides on skin irritability in patients was also examined. Positive reactions were observed in 2 patients, having rosacea like dermatitis and contact dermatitis.
