1986 年 1 巻 3 号 p. 247-256
KK mice are used as model animals for non-insulin-dependent diabetes. In order to better understand the biochemical features of these animals, we compared the activities of various hydrolytic enzymes, including aminopeptidases, endopeptidases, carboxypeptidase, esterase, and so forth in the pancreas and liver of these animals with the same enzymes in ICR mice as controls. The enzymatic changes in the model animals were extensive not only in pancreas but also in liver. Multivariate analysis showed that the metabolic changes in liver rather than in pancreas are closely related to the abnormal glucose metabolism in KK mice. This may be somehow related to the insulin resistance in peripheral tissues in this model.
