Effects of TJ-35 (Shigyaku-san) on Gastric Mucosal Injury Induced by Ischemia-Reperfusion and Its Oxygen-Derived Free Radical-Scavenging Activities

Toshikazu YOSHIKAWA; Shuji TAKAHASHI; Hiroshi ICHIKAWA; Hirohisa TAKANO; Naohiro TASAKI; Mitsunori YASUDA; Yuji NAITO; Toru TANIGAWA; Motoharu RONDO

doi:10.3164/jcbn.10.189

Toshikazu YOSHIKAWA, Shuji TAKAHASHI, Hiroshi ICHIKAWA, Hirohisa TAKANO, Naohiro TASAKI, Mitsunori YASUDA, Yuji NAITO, Toru TANIGAWA, Motoharu RONDO

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Toshikazu YOSHIKAWA
First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Shuji TAKAHASHI
First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Hiroshi ICHIKAWA
First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Hirohisa TAKANO
First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Naohiro TASAKI
First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Mitsunori YASUDA
First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Yuji NAITO
First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Toru TANIGAWA
First Department of Internal Medicine, Kyoto Prefectural University of Medicine
Motoharu RONDO
First Department of Internal Medicine, Kyoto Prefectural University of Medicine

Keywords: TJ-35 (Shigyaku-san), gastric mucosal injury, ischemia-reperfusion, oxygen-derived free radicals, ESR spin trapping method

JOURNAL FREE ACCESS

1991 Volume 10 Issue 3 Pages 189-196

DOI https://doi.org/10.3164/jcbn.10.189

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Abstract

We investigated the effects of TJ-35 (Shigyaku-san) on gastric mucosal injury induced by ischemia-reperfusion in rats; and using the electron spin resonance (ESR) spin trapping method, we also assessed its oxygen-derived free radical-scavenging activities. The increase in mucosal lesions and in thiobarbituric acid-reactive substances (as an index of lipid peroxidation) was significantly inhibited by the oral administration of 500mg/kg of TJ-35; and in addition, TJ-35 demonstrated superoxide and hydroxyl radical-scavenging activities in vitro. These results suggest the possibility that the effects of TJ-35 on gastric mucosal injury induced by ischemia-reperfusion may be the result of its free radical-scavenging activities.

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