1991 年 11 巻 1 号 p. 59-67
In 15 patients with IgA nephropathy, we studied Cu, Zn-SOD localization in glomeruli by immunohistochemistry, and examined the correlation of the clinical findings with the intensity and location of Cu, Zn-SOD specific staining.
In healthy controls, Cu, Zn-SOD was localized in tubules and not in glomeruli. In IgA nephropathy, the enzyme was detected in the glomeruli of 13 out of 15 patients. An inverse correlation was observed between Cu, Zn-SOD stainability and the serum creatinine level. Negative correlation was also observed between Cu, Zn-SOD stainability and the histological grade of sclerosis in IgA nephropathy. We conclude that the study of Cu, Zn-SOD stainability in glomeruli is useful to assess the prognosis in IgA nephropathy.
