Paracetamol as a Radical Scavenger

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It was found that the products of lipid peroxidation in liver homogenates, isolated from paracetamol-treated rats and incubated in presence of Fe²⁺, are significantly lower than those in homogenates from the control rats. The Fe²⁺-induced chemiluminescence in these homogenates was also inhibited. The capacity of liver homogenates isolated from phenobarbital+paracetamol-treated rats to undergo Fe²⁺-catalyzed lipid peroxidation with light emission was decreased with respect to both rats treated with phenobarbital and control rats. Using a phospholipid liposome suspension in which was initiated lipid peroxidation by Fe²⁺, we found that paracetamol possesses concentration-dependent antioxidant action. Paracetamol inhibited also the luminol and lucigenin-dependent chemiluminescence in the xanthine-xanthine oxidase system. In such system for generation of superoxide radicals, paracetamol suppressed the reduction of nitro blue tetrazolium to formazan.
The results obtained showed that paracetamol has antioxidant activity, which may be due to its ability to scavenge lipid and superoxide radicals.