Journal of Clinical Biochemistry and Nutrition
Online ISSN : 1880-5086
Print ISSN : 0912-0009
ISSN-L : 0912-0009
Effect of γ-Oryzanol on Experimental Liver Cirrhosis in Spontaneously Hypertensive Rats (SHR)
Masahiro ITOChao-Tien HSUKazuko SHICHIJOIchiro SEKINE
キーワード: SHR, liver cirrhosis, γ-Oryzanol
ジャーナル フリー

1992 年 12 巻 3 号 p. 193-199


The inhibitory effect of γ-Oryzanol on liver cirrhosis induced by a high-fat diet in spontaneously hypertensive rats (SHRs) was investigated. Eight-week-old SHRs were fed a high-fat diet or a high-fat diet with γ-Oryzanol for 3 months, Lipogenic liver cirrhosis was induced in the animals fed the high-fat diet only. In contrast, supplementation of the diet with γ-Oryzanol suppressed liver cirrhosis and hyperlipidemia in the supplemented group. This study suggests that γ-Oryzanol is very effective against lipogenic liver cirrhosis in the SHR, an animal which possesses natural abnormalities in lipid metabolism.

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