Journal of Clinical Biochemistry and Nutrition
Online ISSN : 1880-5086
Print ISSN : 0912-0009
ISSN-L : 0912-0009
Impact of Quercetin Consumption on Phase-I and Phase-II Drug-Metabolizing Enzymes in Mice
Rajinder Kaur GANDHIKrishan Lal KHANDUJA
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1993 年 14 巻 2 号 p. 107-112

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In the present study Swiss NMRI mice were fed quercetin, a naturally-occurring dietary polyphenolic flavonoid, through their drinking water at dose levels of 0, 1, 3, and 9μg/ml for 8 weeks. There was no change in the hepatic and pulmonary levels of arylhydrocarbon hydroxylase, cytochrome P-450, cytochrome b5, cytochrome c-reductase, or UDP-glucuronyltransferase due to quercetin feeding. However, hepatic activity of glutathione-S-transferase was significantly increased at 3 and 9μg/ml dose levels; and that of the pulmonary enzyme, at 9μg/ml dose. Levels of reduced glutathione were significantly elevated in liver and lungs. These increases in glutathione-S-transferase and reduced glutathione may protect the liver and lungs from the carcinogenic insult of chemicals through the detoxification process.

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