Effects of Protein-Sparing Modified Fasting on Obese Japanese Patients

抄録

A protein-sparing modified fasting diet containing 240kcal per day with supplemental nutrients was used for weight reduction of 15 Japanese patients with obesity. The effects of this treatment on glucose and lipid metabolism, uric acid and hormone levels, and body weight loss were investigated. The rate of body weight reduction was about 500g per day in the first week, and 300g per day thereafter. The average weight loss after 4 weeks was 12% of the initial relative weight obtained from standard body weight. Glucose tolerance was improved, and no significant alterations in the measured variables were observed except positive ketonaria, a slight increase in plasma uric acid during the first 2 weeks, and a decrease in the T₃ level.