Relationship of Fibronectin to C-Reactive Protein, Ceruloplasmin, Alpha-1 Antitrypsin, and Transferrin in Septicemic Children

Abstract

We investigated the relationship between plasma levels of fibronectin and other acute-phase reactant proteins such as C-reactive protein, alpha-1 antitrypsin, ceruloplasmin, and transferrin in children with severe septicemia. The study included 33 Septicemic patients and 10 normal children. Mean plasma fibronectin level was significantly lower in patients on admission (204.7±57.3mg/dl), and was higher after recovery (349.3±89mg/dl), than in normal children (300.2±65mg/dl). No significant difference was found between the mean plasma fibronectin levels of patients with and without meningitis. After the recovery, fibronectin correlated positively with age. No correlation was found between plasma fibronectin and C-reactive protein, transferrin, ceruloplasmin, or alpha-1 antitrypsin levels at any stage of the disease. We concluded that fibronectin has no modulating effect on acute-phase responses of these proteins in severe septicemia.