1999 年 27 巻 1 号 p. 37-47
The effects of administration of vitamin E on hyperoxaluria, hypercalciuria, hyperuricosuria, and hypocitraturia and on the decreased levels of antioxidants such as ascorbic acid, vitamin E, glutathione (GSH), and superoxide dismutase (SOD) in kidney stone patients were observed. Following the surgical removal of kidney stones from the patients, vitamin E (200mg/day) was administered from the 7th day onwards to twenty patients for up to 90 days. The normalization process of urinary risk factors and antioxidants was rapid in the vitamin E-administered patients when compared with that in the untreated group. The increased excretion of citrate following vitamin E administration was suggested to reduce the retention of calcium oxalate crystals and thereby lower the rate of recurrence of stones.
