2000 Volume 28 Issue 1 Pages 15-20
We observed the effect of two soy isoflavones, i.e., daidzin, genistin, and soy extracts on femoral density and urinary bone resorption markers in ovariectomized stroke-prone spontaneously hypertensive rats (OVXSHRSP). Experiment 1: Twenty-five SHRSP, which were fed various soy isoflavones from the age of 5 weeks, were ovariectomized at the age of 19 weeks. Then 3 weeks later, the rats were sacrificed to examine their femurs. Experiment 2: Thirty-five SHRSP received an ovariectomy at the age of 19 weeks, and then various soy isoflavones were given for 2 weeks after the surgery. Twenty-four hour urine was collected before and for 2 weeks after ovariectomy. Femoral density in genistin- or soy extract-treated OVXSHRSP was significantly higher than in untreated OVXSHRSP. Urinary bone resorption markers, pyridinoline and deoxypyridinoline in OVXSHRSP fed genistin, daidzin, or soy extracts were significantly lower than those in untreated OVXSHRSP. These results indicate that soy isoflavones attenuate bone loss in OVXSHRSP.