Oxidative stress is considered to be one of the important etiological factors invarious diseases including gastric ulcers. The mechanism of aspirin induced gastric lesion ismediated through lipid peroxidation. The effects of Cissus quadrangularis extract on aspirin-induced ulceration in rats with respect to its antioxidant status, lipid peroxidation, quantityof mucus and alkaline phosphatase and myeloperoxidase (MPO) activities was estimated.Cissus quadrangularis facilitated the healing of experimental gastric ulcer by increasedmucus content, antioxidant defense enzyme activity and decreased MPO activity and lipidperoxides levels in the gastric mucosa. These results indicate that Cissus quadrangularis extract protects against aspirin-induced gastric mucosal lesions in rats possibly through itsantioxidative action.
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