Anti-Tumor Effects of Chlorpromazine Derivatives on Yoshida Sarcoma Cells and Ehrlich Ascites Tumor

Takayuki OZAWA; Morimitsu NISHIKIMI; Satoru SUGIYAMA; Masayasu KITAZAWA; Junichi SAKAMOTO; Yoshihiro HANAKI

doi:10.3164/jcbn.4.119

Takayuki OZAWA, Morimitsu NISHIKIMI, Satoru SUGIYAMA, Masayasu KITAZAWA, Junichi SAKAMOTO, Yoshihiro HANAKI

著者情報

キーワード: chlorpromazine, chlorpromazine derivatives, anti-tumor effect

ジャーナルフリー

1988 年 4 巻 2 号 p. 119-122

DOI https://doi.org/10.3164/jcbn.4.119

詳細

抄録

Anti-tumor effect of phenothiazine derivatives is widely recognized. The anti-tumor effects of chlorpromazine derivatives on Yoshida sarcoma cells and Ehrlich ascites tumor were investigated. Derivatives in which Cl of chlorpromazine is replaced with Br and the carbon number of the N-side chain is elongated to 4 or 5 were more effective in anti-tumor action than chlorpromazine. Moreover, their LD₅₀ values were much higher than that of chlorpromazine. From these results, these newly synthesized compounds might be considered for clinical trial.

責任著者(Corresponding author)