1988 年 4 巻 2 号 p. 157-163
The inhibitory effects of a synthetic protease inhibitor, FUT-175, on the serum levels of pancreatic enzymes, amylase, trypsin, elastase 1, and lipase, in patients subjected to endoscopic retrograde cholangio-pancreatography (ERCP) were examined by the double-blind method. In the untreated group, serum trypsin and lipase levels reached a peak at 2h after the completion of ERCP; and amylase and elastase, at 6h. The serum levels of amylase and lipase recovered to the normal level on the 3rd day, whereas trypsin and elastase did not recover even by the 5th day. By the treatment with FUT-175 at a dose of 10mg or 40mg/day i.v., the increase in serum trypsin level was significantly reduced 2h after ERCP. In chronic pancreatitis patients, the increase in serum amylase level was significantly inhibited 2h after ERCP. FUT-175 also lowered the increased serum levels of other enzymes, but not significantly. These results suggest that FUT-175 is useful to reduce the pancreatic overloading and complications developing after ERCP.