Immunohistochemical Localization of Vitamin B12 R-Binder in Human Skin Tissues

Yoshiki MIYACHI; Sadao IMAMURA; Gakuji OHSHIO; Tadao MANABE; Hiroyuki KUDO; Masami INADA; Katsuhiko OGAWA

doi:10.3164/jcbn.4.249

Immunohistochemical Localization of Vitamin B₁₂ R-Binder in Human Skin Tissues

Yoshiki MIYACHI, Sadao IMAMURA, Gakuji OHSHIO, Tadao MANABE, Hiroyuki KUDO, Masami INADA, Katsuhiko OGAWA

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Keywords: VB₁₂ R-binder, immunohistochemical distribution, human skin, sweat glands

JOURNAL FREE ACCESS

1988 Volume 4 Issue 3 Pages 249-254

DOI https://doi.org/10.3164/jcbn.4.249

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Abstract

Immunohistochemical distribution of vitamin B₁₂ R-binder, an immunologically distinct vitamin B₁₂-binding protein, was studied in human skin tissues. Positive staining for R-binder was found in normal eccrine glands, syringoma, eccrine poroma, and genital Paget's disease. It is speculated that R-binder plays a role in the local defense mechanism by inhibiting bacterial overgrowth.

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