Altered Urinary Excretion of Hydroxyproline in Nephrotic Syndrome Patients

Abstract

Urinary excretion of hydroxyproline was determined in 15 nephrotic syndrome patients and 15 age-matched controls. The nephrotic patients excreted appreciably higher amounts of amino acids and imino acids compared with normals. On fractionation using Dowex 50×8H⁺ resin column, a greater excretion of large molecular weight hydroxyproline containing fraction (HP fraction 2) was observed compared with the normals, indicating the possibility of altered catabolism of collagen.