Effect of Zinc-Carnosine Chelate Compound (Z-103) on Burn-Induced Gastric Mucosal Injury in Rats

Abstract

The protective effect of a novel synthetic zinc-carnosine chelate compound, zinc N-(3-aminopropionyl)-L-histidine (Z-103), on the gastric injury induced by burn stress was studied in rats. Gastric lesions were produced by immersion of half of the animal's body into 80°C water for 10s. The increase in total area of the erosions 3h after the stress and the increase in thiobarbituric acid reactants in the gastric mucosa were significantly inhibited by the administration of Z-103 at doses of 30, 100, and 300mg/kg. The decrease in blood flow in the gastric mucosa was not influenced by the treatment with Z-103. These results suggest that the protective effect of Z-103 against the aggravation of burn-induced gastric mucosal injury may be due to its inhibitory effect on lipid peroxidation.