2020 年 128 巻 8 号 p. 555-559
β-tricalcium phosphate (β-TCP) with interconnected pores is an attractive substitute for bone because it shows excellent tissue response and osteoconductivity. An interconnected porous structure is a key factor for fast osteoconductivity, because it facilitates tissue and cell penetration. However, it is challenging to attach interconnected porous structure to β-TCP blocks. In this study, a new, simple, and safe method for fabricating interconnected porous β-TCP was developed, based on an analogous dental glass ionomer cement setting reaction. β-TCP granules were mixed with polyacrylic acid (PAA) by loading; PAA got bound to these granules and got set to form an interconnected porous structure; the sintering process decomposed PAA and yielded the interconnected porous β-TCP structure. Diametral tensile strength and porosity of the fabricated samples were 1.3 ± 0.2 MPa and 57.6 ± 1.1%, respectively. These values of samples were enough value for applying bone substitute. β-TCP with interconnected pores synthesized using the novel method described, herein, would be a suitable bone substitute in clinical settings.
