Ha Beads for Bone Regeneration

抄録

We are trying to fabricate porous grafts with an optimum macropore network for bone regeneration by integrating hydroxyapatite (HA) tiny units. In this study, φ1 mm spherical HA ceramics with a φ300 μm through-hole (HA beads) were prepared as a model of the unit. By integrating the HA beads, the through-holes could be connected through gaps between the HA beads, thus constructing an interconnected macropore network. Micro X-ray CT analysis of the integrated HA beads proved that the through-holes and the gaps produced an interconnected network. The macro-porosity of the integrated beads was 47.7±1.9%. Bone regeneration in the macropore network was evaluated by an animal test. After 7 days, favorable developments for bone repair were confirmed in the macropore network. This result showed that the HA beads can be the minimum unit to construct an effective macroporous graft for bone regeneration.