総合報告
金属酵素の結晶構造化学的研究：ヒドロゲナーゼの反応機構について
2021 年 63 巻 2 号 p. 97-104
詳細
2021 年 63 巻 2 号 p. 97-104
The metalloenzyme ‘hydrogenase’ catalyzes the reversible oxidation of dihydrogen. Crystallographic structures of［NiFe］hydrogenases from sulfate-reducing bacteria have been determined and give detailed insight into pathways for the transfer of electrons, protons and hydrogen molecules.［NiFe］hydrogenases contain one nickel and one iron in the active site, the latter carries non-protein diatomic ligands, one CO and two CN－s. A possible catalytic mechanism of the oxygen-sensitive［NiFe］hydrogenases for the heterolytic dihydrogen splitting is proposed.
