真核生物の複製制御因子GINS複合体の構造解析
2007 年 49 巻 5 号 p. 286-291
詳細
2007 年 49 巻 5 号 p. 286-291
The eukaryotic GINS complex is essential for the establishment of DNA replication forks and replisome progression. We report the crystal structure of the human GINS complex. The heterotetrameric complex adopts a pseudo symmetrical layered structure comprising two heterodimers, creating four subunit-subunit interfaces. The structural and biochemical data suggest that the tetrameric complex ensures a stable platform for the C-terminal domain of Psfl to act as a key interaction interface for other proteins in the replication-initiation process.
