Glucose Intolerance and Colorectal Cancer Risk in a Nested Case-Control Study among Japanese People

Kotaro Ozasa; Yoshinori Ito; Koji Suzuki; Yoshiyuki Watanabe; Masayo Kojima; Sadao Suzuki; Shinkan Tokudome; Koji Tamakoshi; Hideaki Toyoshima; Miyuki Kawado; Shuji Hashimoto; Norihiko Hayakawa; Kenji Wakai; Akiko Tamakoshi

doi:10.2188/jea.15.S180

The Japan Collaborative Cohort Study (JACC Study) for Evaluation of Canner Risk sponsored by the Ministry of Education, Science, Sports and Culture of Japan (Monbusho): Report of Selected Results by Site

Glucose Intolerance and Colorectal Cancer Risk in a Nested Case-Control Study among Japanese People

Kotaro Ozasa, Yoshinori Ito, Koji Suzuki, Yoshiyuki Watanabe, Masayo Kojima, Sadao Suzuki, Shinkan Tokudome, Koji Tamakoshi, Hideaki Toyoshima, Miyuki Kawado, Shuji Hashimoto, Norihiko Hayakawa, Kenji Wakai, Akiko Tamakoshi

著者情報

Kotaro Ozasa
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science.
Yoshinori Ito
Department of Public Health, Fujita Health University School of Health Sciences.
Koji Suzuki
Department of Public Health, Fujita Health University School of Health Sciences.
Yoshiyuki Watanabe
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science.
Masayo Kojima
Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences.
Sadao Suzuki
Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences.
Shinkan Tokudome
Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences.
Koji Tamakoshi
Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine.
Hideaki Toyoshima
Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine.
Miyuki Kawado
Department of Hygiene, Fujita Health University School of Medicine.
Shuji Hashimoto
Department of Hygiene, Fujita Health University School of Medicine.
Norihiko Hayakawa
Department of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University.
Kenji Wakai
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute.
Akiko Tamakoshi
Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine.

キーワード: Glucose Intolerance, glycoalbumin, Colorectal Neoplasms, Cohort Studies, Epidemiology

ジャーナルフリー

2005 年 15 巻 Supplement_II 号 p. S180-S184

DOI https://doi.org/10.2188/jea.15.S180

[Correction] Journal of Epidemiology Vol.15 (2005) No.5 p.197_5

詳細

抄録

BACKGROUND: Glucose intolerance may increase the risk of developing colorectal cancer.
METHODS: In a sero-epidemiological nested case-control study, conducted as part of the Japan Collaborative Cohort Study (JACC Study) for Evaluation of Cancer Risk, we measured serum glycoalbumin in 123 patients with colorectal cancer and 279 controls. Conditional logistic regression was used to evaluate the risk of colorectal cancer.
RESULTS: There were trends towards an association between high levels of glycoalbumin and an increased risk of colorectal cancer in men (odds ratio [OR] = 2.39; 95% confidence interval [CI]; 0.89- 6.36) and between high levels of glycoalbumin and a decreased risk of colorectal cancer in women (OR = 0.41; 95% CI, 0.14-1.04).
CONCLUSIONS: A high level of glycoalbumin may increase the risk of colorectal cancer in men. The finding that high levels of glycoalbumin in women decreased their risk of colorectal cancer was inconsistent with previous reports, and may have been the result of limitations in the procedure in selecting samples and statistical power.
J Epidemiol2005; 15: S180-S184.

責任著者(Corresponding author)

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