Flow Injection Biosensor System for in vivo Analysis of Biomolecules in the Extracellular Space of Brain
Mini-Review
2004 年 21 巻 1 号 p. 59-
詳細
2004 年 21 巻 1 号 p. 59-
The in vivo monitoring of the concentration changes of biomolecules at a variety of sites of the living systems including blood stream, subcutaneous tissue, muscle, internal organs, and brain, has been desired for the pharmacological, clinical, and biological studies. The most general approach to achieve such goals was the use of implanted biosensors, but it was limited because of the variations in sensitivity during the prolonged in vivo monitoring. Recently, microdialysis has been used as a sampling technique for in vivo analysis. This article reviews novel flow-injection biosensor systems which make possible on-line monitoring of glucose metabolism and pharmacological behavior of neurotransmitters in the extracellular space of brain. This approach was developed by coupling microdialysate sampling to the biosensor system using a flow-injection interface. The advances in these researches are reviewed with the results obtained in our recent works.
