The Journal of General and Applied Microbiology
Online ISSN : 1349-8037
Print ISSN : 0022-1260
ISSN-L : 0022-1260
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Role of some fermentation parameters on cyclosporin A production by a new isolate of Aspergillus terreus
Lotfy A.R. SallamAbdel-Monem H. El-RefaiAbdel-Hamid A. HamdyHassaan A. El-MinofiIbrahim S. Abdel-Salam
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2003 Volume 49 Issue 6 Pages 321-328


A local isolate of Aspergillus terreus was selected among different microorganisms as a new cyclosporin A (Cy A) producing culture. The formation of Cy A was investigated under different fermentation conditions (including selection of the cultivation medium, fermentation time course, inoculum nature, medium volume, agitation rate, pH value). Relatively high Cy A productivities were maintained when the fermentation process was carried out using a medium composed of (g/L): glucose, 50; bactopeptone, 10; KH2PO4, 5; KCl, 2.5; pH 5.3, inoculated with 2% standard inoculum of 48h age, shaken at 200rpm for 10 days.

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© 2003 by The Applied Microbiology, Molecular and Cellular Biosciences Research Foundation
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