Mumiamicin: Structure and bioactivity of a new furan fatty acid from Mumia sp. YSP-2-79

Tōru Kimura; Ayano Tajima; Yuki Inahashi; Masato Iwatsuki; Hiroaki Kasai; Takayuki Mokudai; Yoshimi Niwano; Kazuro Shiomi; Yōko Takahashi; Satoshi Ōmura; Takuji Nakashima

doi:10.2323/jgam.2017.06.004

Full Papers

Mumiamicin: Structure and bioactivity of a new furan fatty acid from Mumia sp. YSP-2-79

Tōru Kimura, Ayano Tajima, Yuki Inahashi, Masato Iwatsuki, Hiroaki Kasai, Takayuki Mokudai, Yoshimi Niwano, Kazuro Shiomi, Yōko Takahashi, Satoshi Ōmura, Takuji Nakashima

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Keywords: antioxidative activity, furan fatty acid, marine actinomycete, mumiamicin, physicochemical screening

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Supplementary material

2018 Volume 64 Issue 2 Pages 62-67

DOI https://doi.org/10.2323/jgam.2017.06.004

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Abstract

A new antibiotic, designated mumiamicin, was isolated from the cultured broth of the rare actinomycete strain, Mumia sp. YSP-2-79, by Diaion HP-20, silica gel and ODS column chromatography, followed by HPLC purification. The chemical structure of mumiamicin was elucidated as a new furan fatty acid by nuclear magnetic resonance and mass spectrometry. Mumiamicin showed antimicrobial activity and antioxidative activity.

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