The Journal of General and Applied Microbiology
Online ISSN : 1349-8037
Print ISSN : 0022-1260
ISSN-L : 0022-1260
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Microbial inhibitors active against Plasmodium falciparum dihydroorotate dehydrogenase derived from an Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979
Amila PramisandiKazuyuki DobashiMihoko MoriKenichi NonakaAtsuko MatsumotoToshiyuki TokiwaMayuka HigoKristiningrumEri AmaliaArif NurkantoDaniel Ken InaokaDanang WaluyoKiyoshi KitaTomoyoshi NozakiSatoshi ŌmuraKazuro Shiomi
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2020 Volume 66 Issue 5 Pages 273-278

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Abstract

An Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979 was cultured to find novel scaffolds of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. We obtained altenusin (1), which inhibits PfDHODH, with an IC50 value of 5.9 μM, along with other metabolites: mitorubrinol (2) and mitorubrinic acid (3). Compounds 1 and 2 inhibited PfDHODH but displayed no activity against the human orthologue. They also inhibited P. falciparum 3D7 cell growth in vitro. Compound 3 showed little PfDHODH inhibitory activity or cell growth inhibitory activity.

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© 2020, Applied Microbiology, Molecular and Cellular Biosciences Research Foundation
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