The Journal of General and Applied Microbiology
Online ISSN : 1349-8037
Print ISSN : 0022-1260
ISSN-L : 0022-1260
PARTIAL CHARACTERIZATION AND IDENTIFICATION OF A TRANSFERRIN-LIKE MOLECULE OF PATHOGENIC YEAST CRYPTOCOCCUS NEOFORMANS
FISHAYE TESFA-SELASERODRICK J. HAY
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JOURNALS FREE ACCESS

1996 Volume 42 Issue 1 Pages 61-70

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Abstract

We have partially characterized, purified, and N-terminal amino acid sequenced a protein of approximately 80kDa from Cryptococcus neoformans. Of the 15N-terminal amino acids sequenced, 12 are identical to those found in ovotransferrin. Polyclonal antisera raised against ovotransferrin crossreacted with the 80kDa protein. In addition, incorporation of 55Fe indicated the presence of iron binding by the 80 kDa protein. Because Cryptococcus neoformans does not possess an iron-scavenging ligand, siderophore, we suggest that an alternative transferrin-like molecule (the 80kDa protein) may play a role in iron uptake by this organism.

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