抄録
It has been suggested that diabetes mellitus is associated with an increased risk of cancer. Epidemiological data in Japan demonstrate that diabetes is associated with increased risk for total cancers and site-specific cancers at colorectum, liver, and pancreas. Insulin resistance with subsequent hyperinsulinemia is the most frequently proposed hypothesis to explain this link. In addition, several facets of lifestyle including obesity, smoking, and lack of exercise, and treatment for diabetes may also affect the risk of cancer. In light of the exploding global epidemic of diabetes, even a modest increase in the cancer risk will translate into a substantial socioeconomic burden, which led to a joint committee being formed, enlisting experts from the Japan Diabetes Society and the Japanese Cancer Association to address this issue. The current insights underscore the need for clinical attention and better-designed studies of the complex interactions between diabetes and cancer.
