Influence of Long-term Lactose Feeding on Intestinal Alkaline Phosphatase in Rats

Abstract

Lactose is known to enhance passive calcium absorption independent of vitamin D endocrine system. However, the effect of lactose on other metabolism is not fully understood. The purpose of this study was to examine the effects of long-term lactose feeding on intestinal alkaline phosphatase (ALP) activity. A total of 30 female Sprague-Dawley rats (6 weeks old) were divided into three groups, and fed a control diet, a 3% lactose or a 10% lactose diet, respectively. After 56 days, intestinal ALP activity in the ileum from the 3% or 10% lactose group was significantly higher than the control group ( p<0.01, respectively). These data suggest that the long-term lactose feeding influences on intestinal ALP activity.