Abstract
Phosphorus is one of the important minerals related to bone metabolism. In this study, we explored the influences of dietary phosphorus intake on alkaline phosphatase (ALP) and bone metabolism. Male Sprague Dawley rats were divided into four dietary groups: 0.3％ phosphorus control group (P 0.3), 0.15％ phosphorus diet group (P 0.15), 0.5％ phosphorus diet group (P 0.5), and 1.0％ phosphorus diet group (P 1.0) (10 animals/group). Fourteen days after the beginning of the experimental diet, there were no significant differences in ALP-specific activities in the small intestine, liver, or kidney. However, in the P 0.15 group, the levels of ALP activity and cortical bone mineral contents in of the femur had decreased significantly compared with the P 0.3 control group. Furthermore, in the P 0.5 and P 1.0 groups, the cancellous bone mineral density of the femur had decreased significantly compared with the P 0.3 control group. These results suggest that the short-term (14 days) experimental diet of phosphorus restriction or phosphorus loading influenced ALP activity and bone metabolism.
