Abstract
Serum lipid peroxide levels were investigated in normal mice and Ehrlich's ascites tumor-bearing mice after feeding on an excessive amount of α-linolenic acid, iron (II), and vitamins C and E. The serum lipid peroxide levels in the tumor-bearing mice were higher than those in the normal mice regardless of the diet fed. Increased lipid peroxide levels were observed in both the normal mice and tumor-bearing mice when the diet was supplemented with α-linolenic acid. Furthermore, the elevation of lipid peroxide levels was more apparent in the tumor-bearing mice given the diet supplemented with iron (II). Therefore, iron (II) seems to have accelerated the biological production of lipid peroxides, especially in the tumor-bearing mice. In contrast, a decrease in the lipid peroxide levels was found in the normal and tumor-bearing mice given the combination of α-linolenic acid, iron (II), and vitamins C and E. The inhibitory effect of these vitamins on lipid peroxidation was more apparent in the tumor-bearing mice than in the normal mice.
