Inhibition of Lipogenesis and Stimulation of Lipolysis in 3T3 L1 Cells by a Garcinia Extract

Abstract

We studied the influence of a Garcinia extract on the lipogenesis and lipolysis of insulindifferentiated 3T3 L1 cells. After the 2nd week of culture with insulin, the cells exhibited numerous larger intracytoplasmic lipid droplets. This lipogenesis due to insulin was inhibited when the Garcinia extract was administered. When the Garcinia extract was added to the mature adipocytes, the smaller (less than 10μm²) intracytoplasmic lipid droplets selectively disappeared. These data suggest that the Garcinia extract inhibited lipogenesis and stimulated lipolysis.