Abstract
We investigated the effect of an aqueous extract of tempeh (AET) on compound 48/80 (c48/80) -induced histamine release from rat peritoneal mast cells. The tempeh sample was made from soybeans that had been inoculated with Rizopus oligosporus, and the resulting compacted cake was extracted with distilled water. AET inhibited the histamine release induced by c48/80 and transiently increased the level of cAMP. The results of this study indicate that tempeh may possess strong anti-anaphylactic activity in vitro.
