Abstract
Anti-aging medicine means that to decrease the prevalence of age-related diseases such as atherosclerosis and cancer, and intervene against biological process of aging and expand healthy life span. Because of aging research progress and molecular mechanism has been analyzed and clarified gradually, and recent work indicated that aging was a cell biological process with possibility of intervention. Until 1990, aging process had been recognized to be too complicated to prevent. Even now, the mechanism of aging has many theories, but the recent progress was about to clarify the main molecular mechanism of aging. Caloric restriction and oxidative stress theory has been recognized as high evidenced theory of aging.
Certain evidence was not exist for human aging, recent report demonstrated that low body temperature, low insulinemia, and high DHEA-s in serum were found in monkeys with caloric restriction as the markers for long life span. This expanded life span with caloric restriction has benn demonstrated to be mediated by NAD-depended histone deacethylase, Sir2/SirT1. In rat, selfexercise was also demonstrated as a mediator for expanding life span (10%). These finding indicated that caloric restriction and exercise may prevent age-related diseases such as atherosclerosis. Caloric restriction and exercise may also expand human life span and healthy life span. We hope that the future aging research the aging mechanism and expand human health life span, and finally Japan become healthy-aging country.
