Objective: To detect chronic kidney disease (CKD) at an early stage, we introduced the determination of urinary albumin/creatinine (A/C) as a basic item of a comprehensive medical check-up in 2023. This study aimed to compare A/C results with those of conventional qualitative urine protein test strips.
Methods: The results obtained from both methods were compared based on (1) urine protein positive/negative test results, (2) concordance rate between the two in the CKD severity classification, and (3) the relationship between abnormalities in CKD-related items and urinary protein abnormalities judged by each method. A total of 18,310 individuals who underwent comprehensive medical checkups at our institution were examined.
Results: (1) All cases of urine protein (3+) and (2+), excluding three cases, were positive for A/C. The positivity rates for (1+), (±), and (-) were 47.1%, 9.6%, and 3.3%, respectively. (2) In the comparison of the CKD severity classification, the concordance rate of the classification was 71.0%, and the proportion of false negatives and positives was 2.3% and 24.9%, respectively. (3) In the Chi-square test with abnormalities in CKD-related items and proteinuria judged by both methods, P was<0.0001 for all items by A/C. Test strip positivity was not significantly related to systolic blood pressure and blood glucose or HbA1c abnormalities. (P=0.1871 and 0.9960, respectively).
There was a discrepancy between the A/C and urine protein qualitative results, and many false-positive and -negative cases were included in the test strip evaluation. Additionally, a study of CKD-related items showed that the A/C was more relevant than test strips.
Conclusion: The introduction of A/C in comprehensive medical check-ups may contribute to the early detection of CKD.
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