Abstract
Revised version of the Guideline for the Management of Hyperuricemia and Gout,2nd edition has been delivered in jan. 2010. Followings are the main point of guidelines: (1)Hyperuricemia is a major pathogenic factor for urate deposition diseases (gouty arthritis, renal disorder, etc.). It is defined as a disease condition showing a serum urate level exceeding 7.0mg/dl, regardless of sex and age. (2)In women, the risks of lifestyle-related diseases increase with increase in serum urate level, even when it is not more than 7.0mg/dl. Examination for possible underlying diseases and lifestyle guidance should be given; however, drug therapy with urate-lowering drugs is not indicated. (3) Hyperuricemia is broadly classified into the following 3 types: uric acid-overproduction type, uric acid-underexcretion type and combined type. The uric acid clearance rate and creatinine clearance rate are determind for the classification. (4) Hyperuricemia and gout are lifestyle-related diseases. Education and proper guidance aimed at modifying the patients lifestyle play a crucial role in improving the clinical course of the disease with or without drug therapy. (5) Lifestyle modification consists of three parts: nutrition therapy, restriction of alcohol consumption, and recommendation for physical training. Modest weight loss has been shown to reduce serum urate level.
