Health Evaluation and Promotion
Online ISSN : 1884-4103
Print ISSN : 1347-0086
ISSN-L : 1347-0086
40th JHEP conference 2012
Controversy about cholesterol lowering therapy
Satoru Yamada
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2012 Volume 39 Issue 6 Pages 764-770


 Since Japan Society for Lipid Nutrition (JSLN) published their cholesterol guideline in 2010, controversy and confusion occurred between patients and general physicians.
 In this guideline, JSLN criticized several clinical studies which were reffered in guideline of Japan Atherosclerosis Society and JSLN denied the conclusion of guideline of Japan Atherosclerosis Society. Although JSLN claimed that they made their guideline emphasizing all-cause mortality, their guideline did not refer any prospective randomized intervention trial. They made their conclusion without exclusion of confounders. Furthermore, their process was informal consensus development which is called black-box method.
 In general, human can understand the fact, but not the truth. When investigators accumulate the mountains of the facts, they can look into one aspect of the truth.
 JSLN must not consider they have got the truth. They just built their hypothesis. They must prove their hypothesis performing randomized interventional trial and basic research. Until these data would be published, general physicians do not have to read or obey JSLN guideline.

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© 2012 Japan Society of Health Evaluation and Promotion
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