Abstract
We examined the effect of chronic Helicobacter pylori infection on both fasting blood glucose and HbA1c levels. The 18,429 adults who received a medical checkup at Kameda Medical Center Makuhari between January 2010 and December 2010 were enrolled as study subjects. From these study patients, we excluded those with factors which could potentially influence H. pylori, fasting blood glucose and HbA1c levels. The final number of eligible subjects was 16,046.
Using propensity score calculated by multiple logistic regression analysis, we estimated causal effects by matching method and Inverse Probability Weighting. Results indicated that fasting blood glucose levels displayed a significant negative correlation with Helicobacter pylori infection (risk difference: -0.8163, risk ratio: -0.0087, p < 0.0001), while HbA1c levels displayed a nonsignificant negative correlation (risk difference: -0.0089, risk ratio: -0.0017, p=0.0682).
These results raise the possibility that chronic Helicobacter pylori infection may reduce the risk of diabetes mellitus, but the influence is minimal at most
