Abstract
Pepsinogen (PG) method (positive: PGI < 70, PGI/II ratio < 3.0) is useful for investigating the of risk of early gastric cancer however the PG value is influenced by H. pylori infection. After eradication of H. pylori, the conversion of the evaluation of pepsinogen method occurs over 80% (from positive to negative). So the PG method is recommended only before eradication. Recently it has been reported that the PG value is useful for evaluation of H. pylori infection. Sensitivity, specificity of PGII (cut off: 10) for H. pylori infection is 91.0 and 85.7 respectively. In the future it is necessary for a more detailed investigation with reference to PG value and PG method.
