Health Evaluation and Promotion
Online ISSN : 1884-4103
Print ISSN : 1347-0086
ISSN-L : 1347-0086
Original Articles
Factors Correlated with Slower Rates of Arteriosclerosis in the Carotid Arteries
Takashi YamagamiYuchi Naruse
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JOURNAL OPEN ACCESS

2017 Volume 44 Issue 3 Pages 479-484

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Abstract

 Objective: We investigated factors which slow arteriosclerosis in the carotid arteries of subjects at high risk for metabolic syndrome.
 Methods: Research subjects consisted of 114 males aged from 26 to 63 (mean±SD;46.2±8.2) with at least three of the four following metabolic syndrome risk indicators: obesity, hypertension, abnormal lipid metabolism and high blood sugar. We measured the maximum intima media thickness (max IMT) of each of their bilateral carotid arteries in 2009 and again in 2013. We calculated the mean of each bilateral data and the value (mean max IMT) was used in analysis. Cases were divided into two roups: one group included cases whose mean max IMT in 2009 was under 1.1mm and the other group cases whose mean max IMT in 2009 was 1.1mm or greater. We investigated the relationship between increases in mean max IMT over a period of 4 years and the subjects’ 2009 health check data.
 Results: No significant relationship was seen in the latter group (mean max IMT≧1.1mm) between the increase in mean max IMT and the subjects’ overall health indexes. On the other hand, in the former group (mean max IMT≧1.1mm), two factors correlated with an increase in mean max IMT after 4 years. One factor was age. Younger subjects were less likely to show an increase in mean max IMT than older subjects. The second factor was their serum LDL cholesterol level. When serum LDL cholesterol levels were divided into three groups (less than 140mg/dL, 140-159mg/dL and 160mg/dL or greater), cases belonging to the second group which LDL cholesterol level is 140-159mg/dL showed the smallest increase in mean max IMT.
 Conclusion: Our results suggest younger subjects with moderately high serum LDL cholesterol (140-159mg/dL) exhibit slower rates of arteriosclerosis in the carotid arteries where the progression of arteriosclerosis is relatively mild.

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© 2017 Japan Society of Health Evaluation and Promotion
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