2017 Volume 44 Issue 6 Pages 813-818
Background and Aims: For the past decades, the incidence and mortality rate of colorectal cancer (CRC) has been increased in Japan. The association of metabolic syndrome (MetS) and CRC has been reported in several studies, however, individual factors contributing to development of CRC have been obscure, especially in Japan. In the present study, we investigated the risk factors, especially focusing on MetS for development of colorectal adenomatous polyps (CP) as precancerous lesions by using comprehensive health checkup data.
Methods: Among 7,213 subjects who took comprehensive health checkup at our hospital between in August 2012 and July 2015, 1,772 subjects who also underwent screening colonoscopy were analyzed. Demographic characteristics, anthropometric measurements, visceral fat area (VFA), blood pressure and hematological metabolic parameters were assessed. Association between variables and CP was evaluated by univariate analysis, and then by multivariate analysis using multiple logistic regression model. A p value < 0.05 was considered statistically significant.
Results: Of 1,772 subjects analyzed, 506 subjects had CP (28.6%) and 5 had invasive colorectal cancer (0.28%). Four hundred and forty-six subjects were diagnosed as MetS (25.2%) and presence of MetS was significantly associated with CP (p < 0.01). Univariate analysis identified significant association of sex, age, body mass index (BMI), and VFA with prevalence of CP. Logistic regression analysis revealed that sex, age, VFA and abnormal blood glucose, which is one of factors consisting of MetS, were independent factors associated with CP.
Conclusion: The present study demonstrated that male, aging, obesity and MetS might be risk factors for colorectal neoplasia in Japan.
